The growing resistance of bacteria to antibiotics is a major potential threat to public health. Currently, some 25,000 people die as a result of antibiotic resistance in Europe every year. But there is hope. Marc Bonten, Suzan Rooijakkers and Jaap Wagenaar speak to the Ed Kuijper of the RIVM about the risks of the arrival of the superbug and about the necessity of One Health: one health for humans and animals.