Artificial intelligence, big data, biobanks, generative medicine, tissue engineering, stem cell research, tinkering with DNA and reproductive technologies. Technological developments are moving fast and seem to be developing faster than the relevant ethics. Nienke de Graeff, Peter Joosten, Wouter Kollen, Helianthe Kort and Nick Ramsey discuss the moral frameworks regarding the dilemmas facing (applied) research. How far can we go in tinkering with man and where is the line between curing and improving?